The Metamorphosis of Dr. Kafka

With issue 185, J.M. DeMatteis took the reins of Spectacular Spider-Man, kicking his run off with the dark, creepy The Child Within, a story that focused on Harry Osborn becoming the Green Goblin again, and on the escape of the cannibalistic rat-man, Vermin.  In the first few pages, we're introduced to Vermin's therapist, Dr. Ashley Kafka.  As seen here, Dr. Kafka is pretty clearly middle-aged.

" - get six figures worth of plastic surgery before my next appearance!"
(Spectacular Spider-Man #184, written by J.M. DeMatteis, art by Sal Buscema)

She kept turning up beyond that story, and became a full-blown Spider-Man supporting character.  And it is not a good thing to be a Spider-Man supporting character.  All sorts of things can happen to you; you could become a supervillain, or you could marry a supervillain, or your son might become a werewolf, or maybe you'll just get chucked off a bridge and die.  But something even stranger happened to Dr. Kafka.